The Harrison College of Pharmacy and Auburn University’s leadership established the Center for Opioid Research, Education and Outreach, or COACH, in 2019 after identifying the need and recognizing an opportunity to serve our local communities and the state of Alabama. The Harrison College of Pharmacy has an established history of expertise in forensic chemistry, neurosciences, pharmacology, drug delivery, pharmacoepidemiology, and practice-based research. This work helps us better understand substance use disorders, focusing on detection, prevention, and treatment. COACH-affiliated faculty and staff have a long history of conducting vital research in this area. Substance use disorder is a complex problem and will require an interdisciplinary solution for the citizens of Alabama and the region. The Center enables our researchers to unify existing programs and expertise, providing a stronger response to the opioid epidemic. Through our stakeholders and researchers, COACH provides a holistic response to a complex and multifaceted problem. We utilize each area of the center to address the health and wellbeing of those affected by opioids and substance use disorders through conducting innovative research, offering educational programs, and engaging in meaningful outreach efforts.